Set in the Ming Dynasty under the rule of Emperor Zhu Qi Zhen when women doctors were not in practice, Hang Yun Xian comes from a long line of medical practitioners, her family having served as court physicians for several generations. However, ever since her grandfather was falsely accused of medical malpractice, the family stopped practicing medicine and changed their name from Tan to Hang. Yet, Yun Xian is determined to learn medicine and so she does it in secret, except things become difficult when she crosses paths with the Emperor Qi Zhen and his brother Qi Zhu capturing the hearts of both men, thus starting a love story spanning several decades.